Intestinal barrier dysfunction in inflammatory bowel diseases
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چکیده
منابع مشابه
Procoagulatory State in Inflammatory Bowel Diseases Is Promoted by Impaired Intestinal Barrier Function
Inflammatory and immune mediated disorders are risk factors for arterial and venous thromboembolism. Inflammatory bowel diseases (IBD) confer an even greater risk of thromboembolic events than other inflammatory conditions. It has been shown that IBD patients display defective intestinal barrier functions. Thus, pathogen-associated molecular patterns (PAMPs) coming from the intestinal bacterial...
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A critical function of the intestinal mucosa is to form a barrier that separates luminal contents from the interstitium. The single layer of intestinal epithelial cells (IECs) serves as a dynamic interface between the host and its environment. Cell polarity and structural properties of the epithelium is complex and is important in the development of epithelial barrier function. Epithelial cells...
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Recent studies on human inflammatory bowel diseases (IBD) have brought our attention to continued epithelial injury and impaired epithelial regeneration as their key pathophysiological features. In order to develop a novel approach for the treatment of IBD, it is important to understand the ordered process of epithelial repair and the pivotal roles for the epithelial stem cells in this process....
متن کاملDiversity of Intestinal Macrophages in Inflammatory Bowel Diseases
Macrophages as innate immune cells and fast responders to antigens play a central role in protecting the body from the luminal content at a huge interface. Chronic inflammation in inflammatory bowel diseases massively alters the number and the subset diversity of intestinal macrophages. We here address the diversity within the human intestinal macrophage compartment at the level of similarities...
متن کاملIntestinal superinfections in patients with inflammatory bowel diseases.
BACKGROUND Intestinal superinfections may occur in the setting of inflammatory bowel diseases (IBD), complicating the clinical picture and triggering flares of disease. AIMS To report our experience with intestinal superinfections in IBD patients over a three-year period. METHODS Charts of patients hospitalized for moderate-to-severe active disease during the observation period were reviewe...
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ژورنال
عنوان ژورنال: Inflammatory Bowel Diseases
سال: 2009
ISSN: 1078-0998
DOI: 10.1002/ibd.20539